Biogenesis of Heart Rhythm


Over a typical human lifespan, the heart beats over 2 billion times. Every normal heartbeat originates as an electrical signal generated in the sinoatrial node (SAN), the heart’s natural pacemaker, and is then transmitted to the rest of the heart. Our scientific goals are to understand the molecular, cellular, and developmental basis for the initiation of the heartbeat in specialized cardiac pacemaker cells within the SAN, and to understand how the SAN functions to regulate cardiac output dynamically in the context of the normal, aged, and diseased heart. Our ultimate aim is to leverage our scientific discoveries to restore normal heart rhythm to patients suffering from slow heartbeat, irregular heartbeat (atrial fibrillation), and cardiac arrest.

Our interdisciplinary team uses several complementary approaches to advance our mission, including whole animal, ex-vivo, and cellular electrophysiology in mouse models, developmental biology and genomics in genetically modified mice and zebrafish, studies in human induced pluripotent (iPS) stem cell-derived heart cells, and human genetics and bioinformatics.

Click on the links below to learn more about specific project areas.

Plasmids, Protocols, and Reagents

We are happy to share any protocols, reagents or published mouse models that were generated in the lab. For plasmids and protocols, please contact the lab manager, Giselle Galang at For mouse requests, please contact Vasanth directly at Please include “Reagent Request” in subject heading.

Smith Cardiovascular Research Building
555 Mission Bay Blvd South, Room 314
San Francisco, CA 94158
Lab Phone: 415-502-3743