Vedantham Lab
Vasanth

Vasanth Vedantham

Principal Investigator

Vasanth received undergraduate degrees from Yale University in physics and biochemistry, an MD from the Harvard-MIT Health Sciences and Technology Program, and a PhD from the Program in Neuroscience at Harvard University. His dissertation research in the lab of Stephen Cannon used chemical modification and electrophysiological recording to define structure-function relationships that govern gating, pharmacology, and toxin binding in voltage-gated sodium channels. After completing clinical training in internal medicine, cardiology, and cardiac electrophysiology, his postdoctoral work in the lab of Deepak Srivastava at the Gladstone Institute of Cardiovascular Disease explored transcriptional networks in the cardiac conduction system.

In 2010, Vasanth joined the faculty at UCSF as a cardiac electrophysiologist with a mentored basic research position at Gladstone as a K08 awardee in Deepak Srivastava’s Lab.

In 2017, Vasanth started his independent lab within the Cardiovascular Research Institute at UCSF. The lab is exploring development, physiology, and evolution of heart rhythm from a multidisciplinary perspective, with the ultimate aim of developing novel therapies for arrhythmias that are grounded in science and informed by clinical need.

Vasanth is also a practicing clinical cardiac electrophysiologist at UCSF with particular interests in inherited arrhythmia syndromes and arrhythmogenic cardiomyopathies, especially cardiac sarcoidosis.

Giselle

Giselle Galang

Lab Manager

Giselle received her undergraduate degree in microbiology, immunology and molecular genetics from UCLA. She has previously worked in cardiovascular research in the labs of Dr. Kenneth Philipson at UCLA and Dr. Eduardo Marban at Cedars-Sinai. Since 2012, she has been working with Dr. Vedantham and has been the lab manager since 2017.

Hongmei

Hongmei Ruan

Specialist

Hongmei received an MD from North-China Coal Medical College, followed by an MS in Cardiovascular Physiology and a PhD in Cardiovascular Pharmacology at Zhongshan University in China. Over the past 30 years, her research has been focused on cardiomyocyte biology and physiology in heart disease, with particular emphasis on cardiac electrophysiology and arrhythmias. She worked as a postdoctoral fellow with Dr. Yibin Wang at UCLA, and later joined the group as a research scientist. She is a past recipient of an AHA postdoctoral fellowship and scientist development grant during her time at UCLA. Hongmei joined the lab in 2017, and (among other projects) currently leads our efforts in whole animal and cellular electrophysiology, including whole cell patch clamp of isolated cardiac pacemaker cells, ex-vivo electrophysiology studies in isolated mouse hearts, and surgical implantation of transmitters for in-vivo electrocardiography.

Ravi

Ravi Mandla

Junior Specialist

Ravi received an undergraduate degree from UC Berkeley in Molecular and Cell Biology and Education. He currently works on better understanding the epigenetic regulations involved in the development of pacemaker cells, using both computational and molecular biology techniques to do so. He is also interested in better understanding how these regulatory pathways have changed throughout evolution, and how these changes can be translated into better patient therapies.

Catherine

Catherine Jung

Junior Specialist

Catherine graduated from UC Berkeley with a degree in Molecular Environmental Biology. She is interested in how the physiology of the sinoatrial node (SAN) changes in response to different types of physiological and pathological stress.

James

James Engel

Postdoctoral Fellow

James received his B.S. in Human Biology and M.S. in Biology from the University of California, San Diego (UCSD). During his time at UCSD his research in Dr. Jack Dixon’s lab was focused on studying the biochemistry of novel phosphatases and secreted kinases. He then received his Ph.D in Molecular, Cellular and Integrative Physiology at the University of California, Los Angeles (UCLA) in the lab of Dr. Reza Ardehali where he studied the differentiation of human embryonic stem cells to heart field specific cardiomyocytes for the treatment of cardiovascular disease. James was selected to participate in the Amgen Postdoctoral Program and will be collaboratively mentored in the Vedantham Lab at UCSF CVRI and at the Amgen South San Francisco Campus.

Kevin

Kevin Chang

Medical Student

Kevin received an undergraduate degree from Vanderbilt University in Neuroscience and Psychology. He has previously done work in various neuroscience labs studying Alzheimer's Disease, but since starting medical school this past fall, he has developed an interest in cardiology. Kevin is excited to work with Dr. Vedantham in learning more about the underlying physiology of the sinoatrial node (SAN) and leveraging the physiology to explore novel therapeutic approaches to the treatment of arrhythmias.

Amanda

Amanda Soe

Undergraduate

Amanda is an undergraduate student at the University of California, Berkeley majoring in Molecular and Cell Biology. She is interested in learning about heart physiology and function along with the underlying causes of arrhythmias.

Alumni

Prasanna

Prasanna Allu

2017-2019

Kahn Lab - Harvard Medical School

Join the Team!

We are looking for motivated researchers from diverse backgrounds at all levels of prior training to join our group. Potential candidates should contact vasanth.vedantham (at) ucsf.edu.

Postdoctoral Fellows:

We are particularly interested in postdocs with prior experience in computational biology, developmental biology, genomics, or cardiovascular physiology, but will consider any motivated applicants. Interested candidates should send a C.V. with a statement outlining your research background, long-term goals, and a brief proposal for what you want to accomplish in the lab.

Graduate Students:

Stay Tuned! We will soon be affiliated with UCSF graduate programs.

Undergraduates:

Students at University of California, Berkeley, can apply to join the lab via the URAP program. Students at other universities should send their C.V. directly to vasanth.vedantham (at) ucsf.edu. We are particularly interested in students with computational biology backgrounds, but all are welcome to apply.