Selected Key Publications by Topic Area

Cardiac Conduction System Development and Function

Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PKR, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V (2020). ATAC-seq Reveals an Isl1 Enhancer that Regulates Sinoatrial Node Development and Function. Circulation Research, 12 Oct. 2020

Samal, Eva, et al. Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System. In Frontiers in Physiology, vol. 10, 18 Mar. 2019

Vedantham V. (2015). New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development. Trends in Molecular Medicine. 21(12):749-761

Vedantham V, G Galang, M Evangelista, RC Deo and D Srivastava. (2015). RNA Sequencing of Mouse Sinoatrial Node Reveals an Upstream Regulatory Role for Islet-1 in Cardiac Pacemaker Cells. Circulation Research. 116:797-803.

Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, and Black BL. (2014) Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Developmental Biology. 393(2):245-54

Vedantham V, Evangelista M, Huang Y, and D Srivastava (2013). Spatiotemporal Regulation of an Hcn4 Enhancer Defines a Role for Mef2 and HDACs in Cardiac Electrical Patterning. Developmental Biology. 373(1):149-62

Zhao Y, JF Ransom, A Li, V Vedantham, M von Drehle, AN Muth, T Tsuchihashi, MT McManus, RJ Schwartz, and D Srivastava. (2007) Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2. Cell. 129(2):303-317

Cardiac Regeneration

Qian L, Y Huang, CI Spencer, A Foley, V Vedantham, L Liu, SJ Conway, J-D Fu, and D Srivastava (2012). In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 485:593-598

Ieda M, JD Fu, P Delgado-Olguin, V Vedantham, Y Hayashi, BG Bruneau, and D Srivastava (2010) Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors. Cell. 142(3):375-386

Cellular and Molecular Electrophysiology

Vedantham V and SC Cannon. (2000) Rapid and Slow Voltage-Dependent Conformational Changes in Segment IVS6 of Voltage-Gated Na+ Channels. Biophysical Journal. 78(6): 2943-2958

Vedantham V and SC Cannon. (1999) The Position of the Fast Inactivation Gate During Lidocaine Block of Voltage-Gated Na+ Channels. Journal of General Physiology. 113: 7-16

Vedantham V and SC Cannon. (1998) Slow Inactivation Does Not Affect Movement of the Fast Inactivation Gate in Voltage-Gated Na+ Channels. Journal of General Physiology. 111: 83-93

Full List of Publications

2020

Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PKR, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V (2020). ATAC-seq Reveals an Isl1 Enhancer that Regulates Sinoatrial Node Development and Function. In Circulation Research, 12 Oct. 2020

2019

Samal, Eva, et al. Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System. In Frontiers in Physiology, vol. 10, 18 Mar. 2019

Rosenthal DG, Parwani P, Murray T, Petek BJ, Benn BS, De Marco T, Gerstenfeld EP, Janmohamed M, Klein L, Lee BK, Moss JD, Scheinman MM, Hsia HH, Selby V, Koth L, Pampaloni MH, Zikherman J, Vedantham V. (2019). Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.Journal of the American Heart Association. doi: 10.1161/JAHA.118.010952

2018

Szilagyi J, Walters TE, Marcus GM, Vedantham V, Moss JD, Badhwar N, Lee B, Lee R, Tseng ZH, and Gerstenfeld EP. (2018). Surface ECG and intracardiac spectral measures predict atrial fibrillation recurrence after catheter ablation. J Cardiovasc. Electrophysiol. doi: 10.1111/jce.136998 [Epub ahead of print]

Ito H, Badhwar N, Patel AR, Hoffmayer KS, Moss JD, Pellegrini CN, Vedantham V, Tseng ZH, Tanel RE, Hsia HH, Lee RJ, Marcus GM, Gerstenfeld EP, and Scheinman MM. (2018). Use of Programmed Ventricular Extrastimulus During Supraventricular Tachycardia to Differentiate Atioventricular Nodeal Re-Entrant Tachycardia From Atrioventricular Reentrant Tachycardia. JACC Clin Electrophysiol. 4(7):872-880

2017

Szilagyi S, Marcus G, Badhwar N, Lee B, Lee R, Vedantham V, Tseng Z, Walters T, Scheinman M, Olgin J and Gerstenfeld EP. (2017). Atrial Fibrillation Patients with Isolated Pulmonary Veins: Is Sinus Rhythm Achievable? Journal of Cardiac Electrophysiology. 28(7):754-761

Guo X, Vittinghoff E, Vedantham V, Pletcher MJ, and Lee BK. (2017). Trends in Hospitalizations for Cardiac Sarcoidosis in the United States, 2005-2011. Circulation Journal. 81(11):1739-1741

2016

Kawamura M, MM Scheinman, V Vedantham, GM Marcus, ZH Tseng, and N Badhwar. (2016). Clinical and Electrophysiological Characteristics of Incessant Atrioventricular Nodal Re-Entrant Tachycardia. JACC: Clinical Electrophysiology. 2(5):596-602

Nguyen KT, Gladstone RA, Dukes JW, Nazer B, Vittinghoff E, Badhwar N, Vedantham V, Gerstenfeld EP, Lee BK, Tseng ZH, Olgin JE, Scheinman MM, and Marcus GM. (2016). The QT Interval as a Noninvasive Marker of Atrial Refractoriness. Pacing Clin Electrophysiol. 39(12):1366-1372

Roberts JD, Gollob MH, Young C, Connors SP, Gray C, Wilton SB, Green MS, Zhu DW, Hodgkinson KA, Poon A, Li Q, Orr N, Tang AS, Klein GJ, Wojciak J, Campagna J, Olgin, JE, Badhwar N, Vedantham V, Marcus GM, Kwok P-Y, Deo RC, and Scheinman MM. (2016). Bundle Branch Re-Entrant Ventricular Tachycardia. Novel Genetic Mechanisms in a Life-Threatening Arrhythmia. JACC: Clinical Electrophysiology. 3(3):276-288

2015

Hoffmayer KS, Lee BK, Vedantham V, Bhimani AA, Cakulev IT, Mackall JA, Sahadevan J, Rho RQ, Scheinman MM. (2015) Variable Clinical Features and Ablation of Manifest Nodofascicular/Ventricular Pathways. Circulation Arrhythmia and Electrophysiology. 8(1):117-27

Vedantham V, G Galang, M Evangelista, RC Deo and D Srivastava. (2015). RNA Sequencing of Mouse Sinoatrial Node Reveals an Upstream Regulatory Role for Islet-1 in Cardiac Pacemaker Cells. Circulation Research. 116:797-803.

Kawamura M, JC Hsu, V Vedantham, GM Marcus, HH Hsia, EP Gerstenfeld, MM Scheinman, and N Badhwar. (2015). Clinical and Electrocardiographic Characteristics of Idiopathic Ventricular Arrhythmias with Right Bundle Branch Block and Superior Axis-Comparison of apical crux area and posterior-septal left ventricle. Heart Rhythm. 12(6):1137-1144

Ito H, Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Gerstenfeld EP, and Scheinman MM. (2015). The Effect of Direct Current Stimulation versus T Wave Shock on Defibrillation Threshold Testing. Pacing and Clinical Electrophysiology. 38(10):1173-1180

Vedantham V. (2015). New Approaches to Biological Pacemakers: Links to Sinoatrial Node Development. Trends in Molecular Medicine. 21(12):749-761

2014

Kawamura M, Vedantham V, Dewland TA, Scheinman MM. (2014), Incessant long-RP tachycardia: What is the mechanism? Heart Rhythm. 2014. 11(5):904-6

Kawamura M, Badhwar N, Vedantham V, Tseng ZH, Lee BK, Lee RJ, Marcus GM, Olgin JE, Gerstenfeld EP, Scheinman MM. Coupling Interval Dispersion and Body Mass Index are Independent Predictors of Idiopathic Premature Ventricular Complex Induced Cardiomyopathy. J Cardiovasc Electrophysiol. 25(7):756-62

Stepanyan, G, Badhwar N, Lee RJ, Marcus GM, Lee BK, Tseng ZH, Vedantham V, Olgin J, Scheinman M, Gerstenfeld EP. Safety of new oral anticoagulants for patients undergoing atrial fibrillation ablation. J Interv Card Electrophysiol. 40(1):33-8

Singh DK, Viswanathan MN, Tanel RE, Lee RJ, Lee BK, Marcus GM, Olgin JE, Han F, Vedantham V, Tseng ZH, Pellegrini C, Kawamura M, Gerstenfeld EP, Badhwar N, and Scheinman M. His Overdrive Pacing During Supraventricular Tachycardia: A Novel Maneuver for Distinguishing Atrioventricular Nodal Reentrant Tachycardia from Atrioventricular Reciporicating Tachycardia. Heart Rhythm. 11(8):1327-35

Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, and Black BL. (2014) Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Developmental Biology. 393(2):245-54

Kawamura M, Gerstenfeld EP, Vedantham V, Rodrigues DM, Burkhardt JD, Kobayashi Y, Hsia HH, Marcus GM, Marchlinkski FE, Scheinman MM, Badhwar N. (2014) Idiopathic Ventricular Arrhythmia Originating from the Cardiac Crux or Inferior Septum - An Epicardial Idiopathic Ventricular Arrhythmia. Circulation: Arrhythmia and Electrophysiology. 7(6):1152-8

Judson MA, Costabel U, Drent M, Wells A, Maier L, Koth L, Shigemitsu H, Culver DA, Gelfand J, Valeyre D, Sweiss N, Crouser E, Morgenthau AS, Lower EE, Azuma A, Ishihara M, Morimoto S, Tetsuo Yamaguchi T, Shiiubo N, Grutters JC, Rosenbach M, Li HP, Rottoli P, Inoue Y, Prasse A, Baughman RP, Organ Assessment Instrument Investigators TW (includes Vedantham V). The WASOG Sarcoidosis Assessment Instrument: An update of a previous clinical tool. Sarcoidosis Vasc Diffuse Lung Dis. 2014. 18(1):19-27

2013

Vedantham V, Evangelista M, Huang Y, and D Srivastava (2013). Spatiotemporal Regulation of an Hcn4 Enhancer Defines a Role for Mef2 and HDACs in Cardiac Electrical Patterning. Developmental Biology. 373(1):149-62

Vedantham V, WM Jackman, and MM Scheinman. (2013). Unexpected Potential Following Ablation of a Right Atriofascicular Accessory Pathway. Journal of Cardiovascular Electrophysiology. 24(8):939-41

Hsu JC, Badhwar N, Gerstenfeld EP, Lee RJ, Mandyam MC, Dewland TA, Imburgia KE, Hoffmayer KS, Vedantham V, Lee BK, Tseng ZH, Scheinman MM, Olgin JE, Marcus GM. A Randomized Trial of Conventional Transseptal Needle versus Radiofrequency Energy Needle Puncture for Left Atrial Access (The TRAVERSE-LA Study). J Am Heart Assoc. 2013 Sep 17; 2(5)e000428.

2012

Qian L, Y Huang, CI Spencer, A Foley, V Vedantham, L Liu, SJ Conway, J-D Fu, and D Srivastava (2012). In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature. 485:593-598

Hsu JC, N Badhwar, BK Lee, V Vedantham, ZH Tseng, and GM Marcus (2012). Predictors of Fluoroscopy Time and Procedural Failure During Biventricular Device Implantation. American Journal of Cardiology. 110(2):240-245

Mandyam MC, V Vedantham , MM Scheinman, ZH Tseng, N Badhwar, BK Lee, RJ Lee, EP Gerstenfeld, JE Olgin, and GM Marcus. (2012). Alcohol and Vagal Tone as Triggers for Paroxysmal Atrial Fibrillation. American Journal of Cardiology. 110(3):364-368

2011

Nguyen DR, JZ Wang, V Vedantham, and N Badhwar (2011). Odynophagia after atrial fibrillation ablation. Circulation. 123(8):e253-e254

2010

Ieda M, JD Fu, P Delgado-Olguin, V Vedantham, Y Hayashi, BG Bruneau, and D Srivastava (2010) Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors. Cell. 142(3):375-386

Before 2010

Zhao Y, JF Ransom, A Li, V Vedantham, M von Drehle, AN Muth, T Tsuchihashi, MT McManus, RJ Schwartz, and D Srivastava. (2007) Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2. Cell. 129(2):303-317

Vedantham V and SC Cannon. (2000) Rapid and Slow Voltage-Dependent Conformational Changes in Segment IVS6 of Voltage-Gated Na+ Channels. Biophysical Journal. 78(6): 2943-2958

Vedantham V and SC Cannon. (1999) The Position of the Fast Inactivation Gate During Lidocaine Block of Voltage-Gated Na+ Channels. Journal of General Physiology. 113: 7-16

Vedantham V and SC Cannon. (1998) Slow Inactivation Does Not Affect Movement of the Fast Inactivation Gate in Voltage-Gated Na+ Channels. Journal of General Physiology. 111: 83-93

Stern CE, S Corkin, RG Gonzales, AR Guimaraes, JR Baker, PJ Jennings, CA Carr, RM Suguira, V Vedantham and BR Rosen. (1996) The hippocampal formation participates in novel picture encoding: Evidence from functional magnetic resonance imaging, Proc. Natl. Acad. Sci. 93: 8660 - 8665

Shiner D, R Dixson and V Vedantham. (1995) Three Nucleon Charge Radius: A Precise Laser Determination Using Helium-3. Physical Review Letters. 74(18): 3553-7